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Enso Biosciences
Concept Demo | Sarah's Journey
The Patient

Sarah, 34.
More than a statistic.

Diagnosed with Stage II Triple-Negative Breast Cancer.
The guidelines suggest a standard regimen. But Sarah's biology is unique. To find the cure hidden in her cells, we don't just look at one piece of the puzzle—we merge them all.

Multimodal Data Ingestion

image Pathology
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blur_on Omics
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clinical_notes Clinical
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Enso Engine
Sarah

Sarah M.

TNBC, Stage II

High Risk
Biopsy ID BX-9920-A
Treatment Plan Pending Analysis...

The Analysis

Enso processes the H&E slide, extracts patch embeddings, and integrates transcriptomic signals to map Sarah's disease in high-dimensional space.

grid_on Patch Extraction
Breast malignant triple-negative pathology slide

AI Finding: Immune-Excluded Phenotype detected. High fibroblast density isolating tumor nests.

dataset Key Gene Signatures

RNA-Seq Analysis
Gene
Function
Expression
SLC7A2
Arginine transporter, associated with macrophage modulation.
PLXND1
Plexin D1, guides cell migration and angiogenesis.
MTMR7
Phosphatase involved in membrane trafficking.
CASP10
Apoptosis initiator caspase.

Patient Embedding Space

UMAP Projection of Multimodal Embeddings

Responders (Trial A)
Non-Responders
Sarah
Sarah (Current)
Predicted Non-Responder
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Insight

Sarah clusters with patients who failed SoC but responded to Anti-CAF therapy.

The Outcome Comparison

description Standard Guidelines

Protocol 12b

Neoadjuvant Chemotherapy + Pembrolizumab

Predicted Response (pCR) 22%
Risk of Toxicity High
Recommended
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Protocol 12b + Anti-CAF

Targeting the fibroblast shell to enable immune infiltration.

Predicted Response (pCR) 68%

trending_up 3x Improvement